Genome wide classification and characterisation of CpG sites in cancer and normal cells

What is it about?

We sought to identify which CpG sites in DNA are aberrantly methylated across all cancers. This is is important as methylation near genes controls gene expression so these changes in gene expression could be involved in turning a cell cancerous or maintaining it as cancerous. We also describe where these aberrantly methylated sites are in the genome and if they are near genes that are involved in cancer.

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Why is it important?

We used computer software to analyse data from methylation mapping experiments and showed that different cancers have genes in common involved in them.