What is it about?
In this study, we aimed to explain the cause of the severity of Class I G6PD variants [G6PDNashville (Arg393His), G6PDAlhambra (Val394Leu), and G6PDDurham (Lys238Arg)] at the molecular level using bioinformatics approaches,
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Why is it important?
This study can aid in the development of targeted therapies that extend beyond G6PD deficiency for individuals with CNSHA, subsequently improving their quality of life.
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This page is a summary of: A computational study of structural analysis of Class I human glucose-6-phosphate dehydrogenase (G6PD) variants: Elaborating the correlation to chronic non-spherocytic hemolytic anemia (CNSHA), Computational Biology and Chemistry, June 2023, Elsevier,
DOI: 10.1016/j.compbiolchem.2023.107873.
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