What is it about?
A progress of self-assembled drug delivery systems. sPLA2 is highly expressed in tumor tissues. A sPLA2-sensitive gemcitabine prodrug was designed and prepared. The prodrug has a phospholipid structure so that some cancer cytotoxic agents are degradeded by sPLA2, PLC, PLD, in turn. Multiple anticancer agents would accumulate in the cancer cell. High anticancer effect is achieved. More importantly, the prodrug can self-assemble into nanoscale "liposomes" that have tumor targeting function.
Featured Image
Why is it important?
A clever design, a precise synthesis, high tumor targeting, high anticancer effect are combined in one prodrug.
Perspectives
A deep understanding of tumor microenvironment and a clever design may improve the treatment of cancer.
Dr. Yiguang Jin
Beijing Institute of Radiation Medicine
Read the Original
This page is a summary of: Biomimetic nanoassemblies of 1- O -octodecyl-2-conjugated linoleoyl- sn -glycero-3-phosphatidyl gemcitabine with phospholipase A 2 -triggered degradation for the treatment of cancer, Colloids and Surfaces B Biointerfaces, April 2017, Elsevier,
DOI: 10.1016/j.colsurfb.2017.02.001.
You can read the full text:
Contributors
The following have contributed to this page
