What is it about?
Pharmacological modulation of arachidonic acid metabolism by aspirin induced hepatic generation of leukotrienes (LTs) and lipoxins (LXs), thereby increasing hepatic expression of the bile salt export pump Abcb11, which translated in enhanced reverse cholesterol transport,
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Why is it important?
arachidonic acid derivatives are promising therapeutics to treat cardiovascular disease in humans
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This page is a summary of: The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism, Cell Metabolism, November 2014, Elsevier,
DOI: 10.1016/j.cmet.2014.09.004.
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