What is it about?
According to literature, the majority of BRCA-1 associated breast cancers are triple-negative and display a basal-like (BL) phenotype. Metaplastic breast cancers (MBCs) are part of the spectrum of BL, and among them, breast carcinosarcoma (BCS) is a rare, aggressive peculiar subtype. We report a case of BCS in a 35-year-old female who was subsequently found to be BRCA1-mutated. To the best of our knowledge, this is one of the few carcinosarcomas reported in a woman with the BRCA mutation. We also present a short review of the literature
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Why is it important?
interesting case and literature review
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This page is a summary of: Carcinosarcoma of the Breast: An Aggressive Subtype of Metaplastic Cancer. Report of a Rare Case in a Young BRCA-1 Mutated Woman, Clinical Breast Cancer, February 2017, Elsevier,
DOI: 10.1016/j.clbc.2016.08.002.
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