What is it about?
We show that the Ebola virus glycoprotein can be incorporated into non-infectious particles, termed virosomes. Virosomes can serve as antibody decoys and modulate macrophage function. The Interferon induced antiviral host cell protein tetherin inhibits virosome release.
Featured Image
Why is it important?
Our results show that virosomes can interfere with immune control of Ebola virus. Moreover, our findings indicate that tetherin may interfere with Ebola virus spread in two ways: Blockade of release of viral particles and virosomes. Finally, our findings may have implications for antiviral strategies. Thus, virosomes are not infectious and easy to produce and might serve as vaccine candidates.
Perspectives
It will be interesting to determine whether other highly pathogenic viruses also release virosomes to lead the immune system astray. Moreover, our findings have implications for the development of novel antiviral strategies. Thus, virosomes are not infectious and easy to produce and might serve as vaccine candidates.
Professor Stefan Pöhlmann
German Primate Center
Read the Original
This page is a summary of: Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner, Cell Reports, February 2019, Elsevier,
DOI: 10.1016/j.celrep.2019.01.065.
You can read the full text:
Resources
Wie das Ebola-Virus das Immunsystem in die Irre führt
idw - Informationsdienst Wissenschaft
Viral decoys - how the Ebola virus leads the immune system astray
University Tübingen
Viral decoys—how the Ebola virus leads the immune system astray
Medical Express
Virale Täuschkörper verwirren das Immunsystem
Esanum
Wie das Ebola-Virus das Immunsystem in die Irre führt
Medizin Aspekte
Contributors
The following have contributed to this page
