What is it about?
This paper shows that GARNL1/RalGAPα1 is the missing link that connects the insulin-PKB/Akt signaling pathway with the activation of the RalA small GTPase in muscle cells. GARNL1/RalGAPα1 and its phosphorylation and/or binding to 14-3-3s are critical for GLUT4 trafficking through RalA in muscle. In turn, GLUT4 trafficking is required for insulin-stimulated uptake of glucose into skeletal muscles.
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Why is it important?
This paper shows that GARNL1/RalGAPα1 is the missing link that connects the insulin-PKB/Akt signaling pathway with the activation of the RalA small GTPase in muscle cells. GARNL1/RalGAPα1 and its phosphorylation and/or binding to 14-3-3s are critical for GLUT4 trafficking through RalA in muscle. In turn, GLUT4 trafficking is required for insulin-stimulated uptake of glucose into skeletal muscles.
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This page is a summary of: GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins, Cellular Signalling, August 2014, Elsevier,
DOI: 10.1016/j.cellsig.2014.04.012.
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