Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

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Why is it important?

Lung cancer is the leading cause of cancer-related mortality in both men and women worldwide with over 1 million deaths each year, and a 5-year survival below 15%. Non-small cell lung cancer accounts for approximately 85% of all lung cancers. In human patients, GLDC overexpression is significantly associated with higher mortality from lung cancer, and aberrant GLDC expression is observed in multiple cancer types. Our findings helped establish a novel link between glycine metabolism and tumorigenesis, and may provide novel targets for advancing anti-cancer therapy.