Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate

What is it about?

The objective of this study was to evaluate the potential anticonvulsant effect of isopentyl ferulate, a new ester derived from ferulic acid in mice (Mus musculus) subjected to two models of induced seizures.

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Why is it important?

The phenylpropanoids are a group of compounds derived from the carbon skeleton of phenylalanine, which have various neuropharmacological activities. Among these compounds, stands out the ferulic acid that presents several pharmacological activities such as neuroprotective, antidiabetic, anticancer antiinflammatory, antidepressant and mainly antioxidant. In addition, the development of their derivatives that comprise similar chemical structure are promising in relation to a range of new pharmacological properties on the central nervous system, which may be related to neuroprotective action. Despite its promising pharmacological activities, few researches have directed a pharmacological study on phenylpropanoids for the treatment of epilepsy.

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