What is it about?
ESR imaging is a non-invasive tool to analyzing distribution of small molecules in living animals. Nitroxide is a popular ESR-active probe, however, very few is known to pass blood-brain-barier. This paper describe such rare ESR probes for brain imaging in mouse.
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Why is it important?
ESR imaging is a rapidly growing imaging technology without use of radio labeling. Specialized probes for ESR imaging have still been limited.
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This page is a summary of: Novel blood–brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging, Bioorganic & Medicinal Chemistry Letters, October 2016, Elsevier,
DOI: 10.1016/j.bmcl.2016.09.010.
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