Synthesis and antibacterial activity studies of 2,4-di substituted furan derivatives

What is it about?

2,4 disubstitiuted furan derivatives (8A-8M) were prepared from furan-4-carboxylic acid ethyl ester (1). Antibacterial activity of new 2,4 di substituted furan derivatives was studied against Gram (+) and Gram (–) bacteria. 8F, 8E, 8D and 8J were found to be effective against Gram (–) bacteria whereas, 8A and 8L were effective against Gram (+) bacteria. Least MIC value was found as 100 µg/ml against Escherichia coli (for 8D and 8F), and Proteus vulgaris (for 8E and 8F). Antibacterial activity is correlated with different substituents. Products exhibited better antibacterial activities especially towards Streptococcus pyogenes, Proteus vulgaris, and Escherichia coli.

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Why is it important?

In conclusion, the proposed methodology provides better yields compared to previous reports in synthesis of 2,4-di substituted furans. Highest antibacterial activity was exhibited by the compound having methoxy substitution on two ortho positions. Both electron withdrawing and donating groups on phenyl group have shown improved antimicrobial activity on Gram (–) bacteria. Better antibacterial activities of synthesized compounds were observed against Streptococcus pyogenes, Proteus vulgaris, and Escherichia coli.