What is it about?
We conducted this research to examine the therapeutic effects of nicotinamide against hepatocellular carcinoma (HCC) both in vivo and in vitro The cytotoxic activity can be explained by inhibition of HCC-induced increased in the expression of IGF-1 and leads to disturbances in the balance between the cell death signal by PKB and MAPK; and the cell survival signal by Nrf2, directing it towards cell survival signals in normal liver cells providing more protection for body against tumor.
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Why is it important?
A new proposed mechanism for the antitumor activity of nicotinamide
Perspectives
The manuscript gives more details about the tumor biology and the ability of nicotinamide to attenuate HCC.
Prof Dr Mohammed M H Al-Gayyar
Faculty of Pharmacy, University of Mansoura
Read the Original
This page is a summary of: The therapeutic effects of nicotinamide in hepatocellular carcinoma through blocking IGF-1 and effecting the balance between Nrf2 and PKB, Biomedicine & Pharmacotherapy, April 2019, Elsevier,
DOI: 10.1016/j.biopha.2019.108653.
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