What is it about?
In this review, the oncogenic, tumor suppressive, and drug resistance related roles of miRNAs, and their involvement in the pathogenesis and treatment of esophageal cancer were summarized.
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Why is it important?
Many comprehensive miRNA expression profiling studies have appeared in EAC and ESCC tissues. miRNAs clearly play critical roles in the pathogenesis of EAC and ESCC. The number of consistently dysregulated miRNAs have been determined in EC, such as upregulation of miR-21, miR-31, miR-221/222, miR-17-92 polycistron, miR-10b, miR-200c, and miR-373, and down-regulation of miR-375, miR-203, let-7, miR-145, miR-34a, miR-143, miR- 210, and 29c.
Perspectives
Further work to determine the downstream targets of these miRNAs will improve our understanding of their mechanisms of action, which will shed new light on utilizing them clinically as biomarkers or therapeutic targets in esophageal cancer.
Hamed Mohammadi
Read the Original
This page is a summary of: Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer, Biomedicine & Pharmacotherapy, August 2016, Elsevier,
DOI: 10.1016/j.biopha.2016.05.009.
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