Characterization of recombinant antibodies for cancer therapy by infrared spectroscopy

What is it about?

The influence of pH, temperature, and freeze-thaw cycles on the structure of several therapeutic antibodies was studied. Drastic changes of temperature and pH affected the structure to different extents for different antibodies.

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Why is it important?

Therapeutic antibodies need to preserve their structure under a variety of storage and transport conditions. The studied antibodies react differently to some of these conditions.