What is it about?
We prepared a vancomycin laden hydrogel to prevent surgical site infection (SSI). This gel is made from a mix of proteins and chemicals that help it stay stable and effective. The slow release ensures that the antibiotic can fight infections more effectively, providing a steady supply of the medicine where it is needed.
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Why is it important?
Controlled release of suitable antibiotics on the surgical sites could allow maximizing drug efficacy and safety, and therefore achieving a desired therapeutic response.
Perspectives
PF-PEGDA hydrogel is a promising way to deliver vancomycin directly to surgical sites to prevent infections. This hydrogel can be injected and quickly turns into a gel within minutes when exposed to light, making it practical for use during surgeries. The rate at which the drug is released can be easily adjusted to meet different medical needs. Early animal tests have shown that this hydrogel could work well in real medical situations.
Dr. Lifeng Kang
University of Sydney
Read the Original
This page is a summary of: Controlled release of vancomycin from PEGylated fibrinogen polyethylene glycol diacrylate hydrogel, Biomaterials Advances, May 2024, Elsevier,
DOI: 10.1016/j.bioadv.2024.213896.
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