What is it about?
Endothelial cells exposed to TNF-α triggered protein expressions and induced angiogenesis. TNF-α-induced NFκB activation stimulated the production of cytokines, Matrix metalloproteinases (MMPs) and adhesion molecules in human endothelial cells. This study shows the anti-inflammatory effect of CoQ0 downregulated MMP-9/NFκB activation and suppressed the formation of new capillaries of endothelial cells
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Why is it important?
The anti-angiogenic property of CoQ0 was revealed by its anti-inflammatory effect to inhibit TNF-α-induced migration, invasion and tube formation abilities of endothelial cells. This novel finding emphasizes the pharmacological efficacies of CoQ0 to treat inflammation and angiogenesis
Perspectives
CoQ0, the novel analog without isoprenoid side chains, has been reported to exert anticancer properties against human breast/lung cancer cells. This study provides more evidences on the anticancer properties of CoQ0, a key ingredient in Antrodia camphorata, a unique mushroom of Taiwan
Dr. You-cheng Hseu
China Medical University
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This page is a summary of: Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells, Biochemical Pharmacology, November 2015, Elsevier,
DOI: 10.1016/j.bcp.2015.09.003.
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