What is it about?
NS3 helicase is a promising drug target for Zika virus. There is no drug approved for this disease. Understanding the behavior of the protein is key to understanding how to target it with small molecules.
Featured Image
Why is it important?
Extensive computational simulations were performed by our collaborators in Brazil.We show the important conformational changes of the RNA binding loop changing the binding site. This work is also important for our OpenZika efforts.
Perspectives
This work could be very useful for Zika virus drug discovery.
Dr Sean Ekins
Collaborations in Chemistry
Read the Original
This page is a summary of: Molecular dynamics simulations of Zika virus NS3 helicase: Insights into RNA binding site activity, Biochemical and Biophysical Research Communications, October 2017, Elsevier,
DOI: 10.1016/j.bbrc.2017.03.070.
You can read the full text:
Contributors
The following have contributed to this page
