Extracellular S100A4 affects endothelial cell integrity and stimulates transmigration of A375 melanoma cells

What is it about?

A role for high concentrations of extracellular S100A4, a calcium-binding EF-hand protein, in reducing inter-endothelial tight junction integrity has been demonstrated. This may be a mechanism by which melanoma cells can somehow shoot their way into the brain to metastasize. The blocking of this mechanism represents an interesting therapeutic target.

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