What is it about?
Progesterone Receptor Membrane Component 1 (PGRMC1) is an unfortunately named protein that appears to play hitherto unrecognised roles in a variety of important disease. This review focuses on its role in cancer.
Featured Image
Why is it important?
The crystal and NMR structures were recently solved, shedding new light onto the regulation of PGRMC1 functions by heme-mediated dimerisation and post-translational modification. PGRMC1 is emerging as a regulatory nexus hub protein, that acts like a fulcrum to cell differentiation, resulting in contrastingly different outcomes of cell plasticity.
Perspectives
Read the Original
This page is a summary of: The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, July 2016, Elsevier,
DOI: 10.1016/j.bbcan.2016.07.004.
You can read the full text:
Contributors
The following have contributed to this page