What is it about?
We measured the activation of Protein Kinase D1 and 3 in response to treatment with Orexin A We flooded the cells with inactive forms of Protein kinase D1 or 3 and measured calcium movement into the cells in response to Orexin A treatment. Calcium reponses were completely altered showing that in the brain these 2 kinases participate in the response stimulation of receptor by OrexinA
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Why is it important?
We know we need food when the glucose sensing neuron in the brain are inactive because glucose level is low. This gives new insight on how we know that we need food for instance or any other behaviors which are controlled by orexin A
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This page is a summary of: A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, October 2010, Elsevier,
DOI: 10.1016/j.bbamcr.2010.07.001.
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