What is it about?
This research work is about a tumor suppressor gene p53. In this work we have shown that how the mutation in this gene is restored to wild type by Ceramide, a small lipid molecule.
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Why is it important?
This work shows the unique mechanism by which mutation in p53 can be restored. It also shows how Ceramide modulates pre-mRNA spicing to restore mutant p53 to wild type.
Read the Original
This page is a summary of: Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, November 2014, Elsevier,
DOI: 10.1016/j.bbalip.2014.08.017.
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