What is it about?
In this review, we assess the current understanding of this cytokine and focus on the possible roles of IL-22 in autoimmune diseases.
Featured Image
Why is it important?
IL22 plays a critical role in maintaining barrier homeostasis against intestinal pathogens and commensal bacteria. IL22 causes protection and restoration of the epithelial tissues in experimental models such as liver necrosis and inflammatory bowel disease while it can produce a pro-inflammatory response in some other conditions. Therefore, during the chronic phase of some viral infections such as HIV, IL22-producing T cells are significantly reduced and integrity of intestinal epithelium is destroyed.
Perspectives
Extensive studies are necessary to provide a more comprehensive understanding of the differences in the ability IL22 to produce pro- or anti-inflammatory responses in particular situations. Such an understanding of the IL-22 regulation and function provides an opportunity for the development of novel therapeutic practical approaches for many diseases.
Hamed Mohammadi
Read the Original
This page is a summary of: Interleukin-22 in human inflammatory diseases and viral infections, Autoimmunity Reviews, December 2017, Elsevier,
DOI: 10.1016/j.autrev.2017.10.004.
You can read the full text:
Contributors
The following have contributed to this page
