Antiviral lectins: Selective inhibitors of viral entry

What is it about?

The publication reviews the current literature on antiviral lectins that inhibit viral entry. The accepted lectin mechanisms of action are presented along with antiviral lectin structures, selectivities, and bioactivitiese. The therapeutic potential of this class of molecules and future directions are also discussed.

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Why is it important?

Antiviral lectins have enormous preventative potential for topological microbicides against enveloped viruses. Griffithsin is a prime example of a potent lectin (1pM activity against HIV-1) that is efficacious in vaginal topological treatment that cost pennies to manufacture and distribute. Furthermore, some lectins are tolerated systemically and represent a unique class of antiviral therapeutics.