What is it about?
We succeeded (as the first academic lab) in purification of active Zika polymerase and we discovered ATP analogs that inhibit this enzyme.
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Why is it important?
Our ATP analogs can be converted to prodrugs that could be directly used to combat Zika virus.
Perspectives
This was our first article about a viral polymerase. Our lab is new in this field, therefore, I am especially glad that we were the first lab to purify active Zika polymerase.
Evzen Boura
Institute of Organic Chemistry and Biochemistry
Read the Original
This page is a summary of: Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase, Antiviral Research, January 2017, Elsevier,
DOI: 10.1016/j.antiviral.2016.11.020.
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Contributors
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