What is it about?
We combined a surface analysis method (Secondary Ion Mass Spectrometry, SIMS) to immunohistochemistry in order to visualize lipids that have accumulated in coronary arteries in different stages of atherosclerosis. Cholesterol was found to accumulate differently from triglycerides. Interestingly, also the lipid content of media was altered.
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Why is it important?
The different accumulation patterns of triglycerides and cholesterol propose that in addition to LDL, also triglycerice-rich VLDL and chylomicron remnants enter the artery intima and are important in atherosclerosis development.
Perspectives
Combining a surface analysis to histology gave us an opportunity to see beneath the histology.
Dr Satu Lehti
Wihuri Research Institute
Read the Original
This page is a summary of: Spatial Distributions of Lipids in Atherosclerosis of Human Coronary Arteries Studied by Time-of-Flight Secondary Ion Mass Spectrometry, American Journal Of Pathology, May 2015, Elsevier,
DOI: 10.1016/j.ajpath.2015.01.026.
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