What is it about?
Ever had that annoying, burning feeling in your eyes? Scientists are studying a condition called neuropathic corneal pain (NCP) to understand it better. Here's what they did and found: What they wanted to know: Researchers wanted to learn more about NCP by looking at tears, taking special pictures of the eye, and understanding patients' symptoms. How they did it: They studied 40 people - 20 with NCP and 20 without. Everyone went through eye tests, filled out questionnaires about their eye problems, and had super close-up pictures taken of their eyes. The scientists also collected tears to analyze what was in them. What they found: NCP patients often complained about burning eyes and being extra sensitive to light. The tears of NCP patients had different proteins compared to people without NCP. Some of these proteins are involved in nerve function and healing. NCP patients had less sensitive corneas (the clear front part of the eye) and changes in their eye nerves. Their corneal nerves were thinner, shorter, and less dense. NCP patients had more tiny nerve growths called microneuromas. The cells on the surface of their eyes were smaller. They had higher levels of a substance called nerve growth factor in their tears.
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Photo by Aarón Blanco Tejedor on Unsplash
Why is it important?
Why it matters: Understanding these differences can help doctors diagnose NCP better and might lead to new ways to treat it in the future.
Perspectives
NCP is a critical problem that bugs patients. Sometimes there is confusion between dry eye and NCP.
Prof Louis Tong
National University of Singapore
Read the Original
This page is a summary of: Neuropathic Corneal Pain: Tear Proteomic and Neuromediator Profiles, Imaging Features, and Clinical Manifestations, American Journal of Ophthalmology, September 2024, Elsevier,
DOI: 10.1016/j.ajo.2024.03.015.
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