What is it about?
GPRC5A was first discovery as a phorbol ester induced gene (PEIG1, phorbol ester induced gene 1). Two years later it was rediscovered as a retinoic acid induced gene and the original findings where negleted for unknown reasons. Here we describe how it was found and also further characterize its regulation by TPA.
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Why is it important?
GPRC5A define a new family of genes. It is an orphan receptor. It has at least one important function, as adirect inhibitor of EGFR. It nay act therefore as a tumor supresor gene.
Perspectives
We are studying a possible role in innate immunity.
Dr Tomás A. Santa Coloma
Institute for Biomedical Research (BIOMED), CONICET, UCA
Read the Original
This page is a summary of: Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene, Archives of Biochemistry and Biophysics, July 2020, Elsevier,
DOI: 10.1016/j.abb.2020.108375.
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