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Activated platelets degranulate to release agents important for primary haemostasis. Intracellular Ca2+ mobilization is essential for α- and δ-granule α-granule secretion occurs rapidly upon platelets stimulation with Exogenous Ca2+ entry is necessary for the exocytosis of δ-granule but not α-granules. Canonical transient receptor potential-6 (TRPC6) function is important for δ-granule secretion.
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This page is a summary of: Relationship between calcium mobilization and platelet α- and δ-granule secretion. A role for TRPC6 in thrombin-evoked δ-granule exocytosis, Archives of Biochemistry and Biophysics, November 2015, Elsevier,
DOI: 10.1016/j.abb.2015.09.012.
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