What is it about?
The article describes a microfluidic paper-based analytical device immunoassay for detection of D-dimer, a blood native biomarker helpful in diagnosing diseases like disseminated intravascular coagulation, deep vein thrombosis and pulmonary embolism.
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Why is it important?
Microfluidic paper-based analytical devices are an ideal technology to develop Point-Of-Care testing. The approach is especially attractive in the context of emergency situations that require an on-the spot result, e.g of the levels of D-dimer in the blood of patients.
Perspectives
Still need to overcome a few shortcomings for μPAD immunoassays to compete with Lateral Flow Immunoassays.
Professor Duarte Miguel Prazeres
Instituto Superior Técnico
Read the Original
This page is a summary of: Colorimetric detection of D-dimer in a paper-based immunodetection device, Analytical Biochemistry, September 2017, Elsevier,
DOI: 10.1016/j.ab.2017.09.009.
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Resources
Immunodetection of D-dimer on a microfluidic paper-based analytical device
The video shows the detection of D-dimer in a wax-printed microfluidic paper-based analytical device (µPAD).
Optical microscopy image of a black line wax-printed on chromatographic paper
This image shows a black line with a width of 500 micron wax-printed on a piece of chromatographic paper (Whatman N. 1). These wax-lines are used to delimit channels in the microfluidic paper-based analytical devices described in the article.
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