What is it about?
The ability to analyze the distribution of topoisomers in a plasmid DNA sample is important in the context of gene therapy, DNA vaccination and biochemical studies. We developed a multimodal chromatography method that achieves baseline separation of supercoiled and open circular topoisomers.
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Why is it important?
The method can be used to evaluate the quality of preparations intended for gene therapy and DNA vaccination.
Read the Original
This page is a summary of: Separation of plasmid DNA topoisomers by multimodal chromatography, Analytical Biochemistry, June 2016, Elsevier,
DOI: 10.1016/j.ab.2016.03.012.
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