What is it about?
The synthetic chemistry and biological testing that are needed to successfully create new antibacterial drugs
Featured Image
Why is it important?
Bacterial resistance to antibiotics is inevitable as a consequence of evolution in the face of the selection pressure of usage. Therefore a continued supply of new antibiotics is needed. This paper shows how new antibacterial agents can be discovered based on finding inhibitors of molecular targets of bacteria.
Perspectives
The field is important because at the time of writing, no new antibacterial agent derived from synthetic chemistry projects mounted against bacterial molecular targets have yet received clinical approval. This review describes the principles that need to be followed, and provides a case history of a compound series that reached human testing.
Wright Nichols
Consultant Microbiologist
Read the Original
This page is a summary of: Design of Antibacterial Agents, January 2015, Elsevier,
DOI: 10.1016/b978-0-12-397169-2.00034-2.
You can read the full text:
Contributors
The following have contributed to this page
