What is it about?
This is a book chapter on MR1: MHC-related protein 1. The article starts with a basic overview of the molecule in immunology aimed at an undergarduate level and then progresses to a more detailed review of the subject at postgraduate level.
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Why is it important?
MR1 is essential for the activation of MAIT cells. These are very abundant white blood cells and must play a very imporant role in teh human immune system because MR1 and MAIT cells have been conserved in evoluation for over 150 million years in animals as diverse as humans, mice and possums.
Perspectives
This is a comprehensive introduction to teh MR1-MAIT TCR interaction based on the work of Prof Jim McCluskey and his research group at the University of Melbourne
Timothy SC Hinks
University of Oxford
Read the Original
This page is a summary of: MR1 (in Mouse and Man), January 2016, Elsevier,
DOI: 10.1016/b978-0-12-374279-7.06018-5.
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