What is it about?
Hyperthermia mediated cispatin delivery system where cisplain is encapsulated by a heat-senstive liposome at hypertermal temperature 42 degree and it is released at the heated tumor.
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Why is it important?
Heat-sensitive liposome is prepared by the composition of DPPC: DSPC (=9:1) (phase-transition temperature, around 42 degree) so that the liposome can release an encapsulated agent at this narrow range of temperatures (41 to 45).
Perspectives
This delivery system is useful for targeted anti-cancer therapy.
Dr Katsumi Iga
Doshisha Joshi Daigaku
Read the Original
This page is a summary of: Cisplatin-entrapping thermosensitive liposome for tumor targeting I: Increased tumor cisplatin-levels, International Journal of Immunopharmacology, January 1988, Elsevier,
DOI: 10.1016/0192-0561(88)90239-1.
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