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Why is it important?
It used to be thought that NADP+ GDHs and 'dual' GDHs were evolutionarily closely related and NAD+ GDHs much more distantly so. Emerging sequences blew this idea out of the water. Journals held up publication of this conceptual shift for several years until it could be hung (in this paper) on a 3D structural framework.
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This page is a summary of: The partial amino acid sequence of the NAD -dependent glutamate dehydrogenase of Clostridium symbiosum: implications for the evolution and structural basis of coenzyme specificity, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, November 1991, Elsevier,
DOI: 10.1016/0167-4838(91)90001-g.
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