What is it about?
No abnormalities in magnetic resonance images were recorded in patients with posttraumatic stress disorder other than an increased incidence (50%) of a small cleft in the callosal-septal interface, a cavum of the septum pellucidum. A similar grade of cavum was obtained in 14% of normal volunteers matched for age, socioeconomic background, and military experience. The cavum is believed to have antedated the disorder and is conceived to be a neurodevelopmental aberration. The possibility that the cavum is a marker of vulnerability to stress in psychopathology is discussed.
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Why is it important?
The question of neurodevelopmental aberration, viewed historically, is addressed in this chapter: Glicksohn, J. (2002). Criminality, personality and cognitive neuroscience. In J. Glicksohn (Ed.), The neurobiology of criminal behavior (pp. 3-24). Boston: Kluwer Academic.
Perspectives
The second major paper stemming from my postdoctorate. We had anticipated seeing differences in structural asymmetry (using MRI) between our PTSD group and our controls. What Prof. Myslobodsky readily observed was a relatively high incidence of cavum septi pellucidi in the coronal scans. This is an intriguing finding, which has since been followed up and cited in the literature.
Professor Joseph Glicksohn
Bar-Ilan University
Read the Original
This page is a summary of: Changes of brain anatomy in patients with posttraumatic stress disorder: A pilot magnetic resonance imaging study, Psychiatry Research, October 1995, Elsevier,
DOI: 10.1016/0165-1781(95)02708-5.
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