What is it about?
There exist several DNA adenine methylation sites in the replication origin of E.coli(oriC). We compared the initiation site in methylated origin and unmethylated. No difference was observed during in vitro DNA replication started from oriC.
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Why is it important?
This work was the starting point for all studies on Dam methylation and negative control of DNA replication.
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This page is a summary of: In vitro replication of a dam methylated and non-methylated ori-C plasmid, Journal of Molecular Biology, June 1984, Elsevier,
DOI: 10.1016/0022-2836(84)90386-3.
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