What is it about?

This research examines fecal shedding of SARS-CoV-2 RNA in people infected with different variants, including the recent JN.1 and BA.2.86 variants. The study analyzed 856 stool samples from 113 non-hospitalized individuals with confirmed COVID-19. The researchers found that people infected with JN.1 and BA.2.86 variants shed significantly higher amounts of viral RNA in their feces compared to those infected with earlier variants like XBB.1.5. This increased shedding was observed in both symptomatic and asymptomatic individuals, as well as in those who were vaccinated. The study also noted that some people shed viral RNA in their feces before showing symptoms.

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Why is it important?

This study provides the first detailed look at how newer variants of SARS-CoV-2, particularly BA.2.86 and JN.1, shed in feces compared to earlier variants. The researchers found that these newer variants result in higher levels of virus being shed in feces, even in people who were vaccinated or didn't have symptoms.

Perspectives

This study provides important insights into how newer SARS-CoV-2 variants, particularly BA.2.86 and JN.1, shed in feces. The findings of increased viral shedding, even in vaccinated and asymptomatic individuals, have significant implications for understanding transmission dynamics, improving wastewater surveillance, and informing public health strategies.

Assoc. Prof. Charin Modchang
Mahidol University

Read the Original

This page is a summary of: Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1, The Lancet Infectious Diseases, June 2024, Elsevier,
DOI: 10.1016/s1473-3099(24)00155-5.
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