What is it about?
Circulating extracellular vesicles (EVs) are small membrane-encapsulated particles that can act as potent vehicles via their cargos between different hepatic cell types and also between organs, because of their ability to transfer proteins, lipids, and nucleic acids to affect the recipient cells' related physiological functions. Hence, the issues related to the potential use of EVs as biomarkers in liver disease diagnosis, prognosis, and even to assess the response to treatment have been handled in my review.
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Why is it important?
The emerging role of non-invasive diagnostic/therapeutic tools in different stages of liver disease represents an area of great interest, which could differ in the clinical outcome of liver disease patients. Over a decade, several studies have thoroughly discussed and evaluated the emerging role of circulating extracellular vesicles (EVs) in different liver diseases.
Perspectives
As potential diagnostic tools, EVs have shown promising results but for further evaluation as therapeutic targets in various liver diseases.
Lecturer Nourhan Badwei
Ain Shams University
Read the Original
This page is a summary of: The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?, iLiver, March 2024, Tsinghua University Press,
DOI: 10.1016/j.iliver.2024.100078.
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