What is it about?
PC4 participates in the initiation, elongation, and termination of RNA polymerase II–mediated transcription. However, extensive research on the PC4 gene has determined that PC4 is also closely associated with DNA damage repair, chromatin formation, and cell cycle regulation.
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Why is it important?
thetumor-promoting effect of PC4 has recently received much attention from scholars. A strong correlation has been revealed between PC4 and the proliferation, metastasis, and therapy resistance of malignant tumors such as esophageal squamous cell carcinoma, non–small cell lung cancer, pancreatic ductal adenocarcinoma, breast cancer, and prostate cancer.
Perspectives
This study explored the PC4 gene level in HCC and the association between gene expression and diagnosis, prognosis, and immune infiltration. Additionally, this study constructed and validated a risk signature for effective assessment of patient prognosis and immunotherapy response. Finally, establishment of the competing endogenous RNA (ceRNA) network facilitates understanding of the regulatory mechanism of PC4 in HCC.
Liangliang Bai
Yan'an University
Read the Original
This page is a summary of: Identification of positive cofactor 4 as a diagnostic and prognostic biomarker associated with immune infiltration in hepatocellular carcinoma, iLiver, December 2023, Tsinghua University Press,
DOI: 10.1016/j.iliver.2023.08.007.
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