Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-l-lysine dendrons

Nurlina Rosli, Michelle P. Christie, Peter M. Moyle, Istvan Toth
  • Bioorganic & Medicinal Chemistry, May 2015, Elsevier
  • DOI: 10.1016/j.bmc.2015.03.058

What is it about?

This article compares the capacity of poly-L-lysine cationic dendrons attached to various cell penetrating peptides (CPPs) to deliver plasmid DNA into cells. Three CPPs are assessed: TAT(48-60), NRTN(132-161) and the shorter NRTN(145-161).

Why is it important?

"delivery, delivery, delivery" is the major problem facing the development of non-viral gene delivery systems. The combination of different components to get around the many barriers to gene delivery represents a promising means to produce efficient non-viral gene delivery systems. In this article we assess a family of promising cell-penetrating peptides (NRTN peptides) and compare them with the gold standard TAT(48-60) peptide. This paper provides important information relating to the effects of different CPPs on the successful delivery of plasmid DNA into cells.

Perspectives

Dr Peter Michael Moyle (Author)
University of Queensland

This is one of the first publications to compare NRTN cell penetrating peptides (CPPs) to the gold standard CPP TAT(48-60) for the delivery of plasmid DNA into cells.

The following have contributed to this page: Dr Peter Michael Moyle