What is it about?
This article compares the capacity of poly-L-lysine cationic dendrons attached to various cell penetrating peptides (CPPs) to deliver plasmid DNA into cells. Three CPPs are assessed: TAT(48-60), NRTN(132-161) and the shorter NRTN(145-161).
Why is it important?
"delivery, delivery, delivery" is the major problem facing the development of non-viral gene delivery systems. The combination of different components to get around the many barriers to gene delivery represents a promising means to produce efficient non-viral gene delivery systems. In this article we assess a family of promising cell-penetrating peptides (NRTN peptides) and compare them with the gold standard TAT(48-60) peptide. This paper provides important information relating to the effects of different CPPs on the successful delivery of plasmid DNA into cells.
The following have contributed to this page: Dr Peter Michael Moyle