Multiple Endocrine Neoplasia type 1 Syndrome and GEP-tumors. Gentoype-phenotype correlation

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Patients with this tumour tumour syndrome must be assessed in a specifically and highly organised clinical management path that includes figures, in addition to the endocrinologist experienced in these syndromes, such as medical geneticists, surgeons with high experience in the field (in particular parathyroid surgery and the abdominal - pancreatic neuroendocrine tumors), nuclear medical, psychologists, appropriate nursing staff and, not least, the family doctor who is to be specially educated. Quite recently, it has been reported that small molecules such microRNA act as important regulators of gene activity and a single microRNA can have significant effects, influencing hundreds of gene transcripts and determining a general change in cell physiology. In fact, microRNAs have a major role in cancer and, in early future, we hope that molecular data on possible involvement of specific miRNAs and epigenetic information also in MEN1-associated tumors in order to develop new therapeutical strategies other than the current utilized.

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