What is it about?
This study covers the formulation and pharmacokinetic study of fast-dissolving flurbiprofen tablets using PEG 6000 (hydrophilic carrier) and lactose (adsorbent).
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Why is it important?
Developing amorphous solid dispersions with good flow properties is always challenging for formulation scientists to convert into tablets. Hence, the present study investigates the impact of the combination of melt-dispersion and surface adsorption methods to prepare melt-dispersion granules with enhanced dissolution rate and flow properties.
Perspectives
Melt-dispersion granules could be a promising strategy to enhance the dissolution rate and bioavailability with improved flow properties by reducing the stickiness of solid dispersion powder mixtures.
Dr Sateesh Kumar Vemula
University of Mississippi
Read the Original
This page is a summary of: Quality by design (QbD) approach to develop fast-dissolving tablets using melt-dispersion paired with surface-adsorption method: formulation and pharmacokinetics of flurbiprofen melt-dispersion granules, Drug Delivery and Translational Research, July 2023, Springer Science + Business Media,
DOI: 10.1007/s13346-023-01382-z.
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