What is it about?
This study investigated the effects of regular exercise by voluntary wheel running (VWR) on cardiometabolic risks induced by fructose ingestion and examined the potential underlying mechanisms.
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Why is it important?
We provided new evidence that voluntary exercise effectively prevented insulin resistance of skeletal muscle glucose transport activity induced by fructose ingestion, which was accompanied by restoration of insulin action on the functionality of signaling elements in the insulin and MAPK pathways. We also presented evidence that the progression of hypertension and dysregulation of glucose disposal at the systemic level in fructose-ingested rats can be protected by voluntary exercise
Perspectives
Our findings underscore the health benefits of being physically active for the prevention of cardiometabolic abnormalities.
Vitoon S
Mahidol University
Read the Original
This page is a summary of: Voluntary exercise opposes insulin resistance of skeletal muscle glucose transport during liquid fructose ingestion in rats, Journal of Physiology and Biochemistry, June 2018, Springer Science + Business Media,
DOI: 10.1007/s13105-018-0639-8.
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