What is it about?
A receptor molecule (CD44) found on the surfaces of brain tumour (glioma) cells is known to be involved in cancer cell spreading (migration, attachment and invasion). By removing this receptor (silencing the gene), we show that the machinery (cytoskeleton) that enables the cancer to spread was partially disabled, delaying it's progress.
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Why is it important?
Understanding what can delay the invasion of brain tumours into normal brain cells is critical in fighting this deadly disease. This paper points to one such method.
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This page is a summary of: Silencing of CD44 in Glioma Leads to Changes in Cytoskeletal Protein Expression and Cellular Biomechanical Deformation Properties as Measured by AFM Nanoindentation, BioNanoScience, December 2015, Springer Science + Business Media,
DOI: 10.1007/s12668-015-0189-2.
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