What is it about?
Ultrasound-sensitive systems are widely applied for external stimulation-responsive drug delivery as well as for ultrasonography in the diagnosis of various diseases. This was the first time the hydrophobic phase-transitional imaging agent was encapsulated into the vesicular lumen to achieve highly efficient tumor site-specific release and tissue-penetrating delivery of anticancer drug in vivo.
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Why is it important?
We propose an unusual approach to preparation of US-sensitive nanospheres possessing multiple distinct features including nanoscale dimensions, a narrow size distribution, and incorporation of a hydrophobic phase-transitional imaging agent into the aqueous lumen, which are crucial for US-assisted drug delivery to solid tumors.
Perspectives
The external stimulation-responsive drug delivery system show great advantages in cancer therapy, such as increase the controllability of drug release as well as decrease the adverse effects. I do hope this article can bring some inspirations to the readers in designing the external-sensitive carriers for drug delivery.
Yong Wang
Read the Original
This page is a summary of: Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery, Nano Research, December 2017, Tsinghua University Press,
DOI: 10.1007/s12274-017-1939-y.
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