What is it about?
The present work was intended to develop the ibuprofen-Kollicoat® MAE 100P delayed-release pellets using hot melt extrusion technology, which exhibits pH-dependent solubility. Ibuprofen irritates the gastric lining, so its release in the gastric environment is not desired. Conventionally, Kollicoat® MAE 100P has been used as an enteric coating polymer, and we have explored its application using hot-melt extrusion technology in our work.
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Why is it important?
This work proves that Kollicoat® MAE 100P could be used in modified-release dosage forms to attain the delayed-release pellets using hot melt extrusion technology.
Perspectives
This article will explain the role of Kollicoat® MAE 100P in the preparation of ibuprofen delayed-release pellets using hot melt extrusion technology,
Dr Sateesh Kumar Vemula
University of Mississippi
Read the Original
This page is a summary of: Development of Delayed-Release Pellets of Ibuprofen Using Kollicoat® MAE 100P via Hot-Melt Extrusion Technology, Journal of Pharmaceutical Innovation, July 2023, Springer Science + Business Media,
DOI: 10.1007/s12247-023-09758-x.
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