What is it about?
The interaction of pres1 region of hepatitis B virus B-cell epitope antigen with specific hepatitis B neutralizing monoclonal antibody was examined by docking study. We modelled the 3D complex structure of B-cell epitope antigen residues CTTPAQGNSMFPSCCCTKPTDGNCY by homology modelling and docked it with the crystal structure of monoclonal antibody specific for the pres1 region of the hepatitis B virus.
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Why is it important?
The interactions between the amino acids of antigen and antibody conferring stability to the docked complex were examined. The stability of the docked antigen–antibody complex is due to hydrogen bonding and van der Waals interactions. The amino acids of the antigen and antibody responsible for the interaction were identified.
Perspectives
The antigen–antibody complex is stabilised by inter-molecular hydrogen bonding interactions and van der Waals interactions. The amino acids of the antigen and antibody responsible for the interaction were identified.
E.J. Padma Malar
University of Madras
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This page is a summary of: Docking of B-cell epitope antigen to specific hepatitis B antibody, Journal of Chemical Sciences, September 2007, Springer Science + Business Media,
DOI: 10.1007/s12039-007-0069-6.
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