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Sirtuins are important modulators of adipose tissue metabolism and their expression is higher in lean than obese subjects. Authors determined that expression of sirtuins in adipose tissue-derived stromal/stem cells varies in a region-specific manner. The results highlight the in fluence of obesity on the SIRTs ’ expression, a possible mechanism through which SIRTs are involved in obesity-associated inflammation, as well as the interplay with PPAR δ.

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This page is a summary of: Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia, Endocrine, November 2016, Springer Science + Business Media,
DOI: 10.1007/s12020-016-1170-8.
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