What is it about?
DMARDs are most effective drugs yet their uses are limited due to hepatotoxicity. Nanoformulations provide local effect with easy uptake by synovial macrophages therefore, capable of avoiding hepatic illness.
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Why is it important?
Avoid hepatotoxicity of drugs in combination by using dose minimization approach
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This page is a summary of: Co-Delivery of Teriflunomide and Methotrexate from Hydroxyapatite Nanoparticles for the Treatment of Rheumatoid Arthritis: In Vitro Characterization, Pharmacodynamic and Biochemical Investigations, Pharmaceutical Research, September 2018, Springer Science + Business Media,
DOI: 10.1007/s11095-018-2478-2.
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