gabapentin-loaded cellulose acetate/gelatin electrospun scaffold for neural tissue regeneration

What is it about?

A 3D fibrous scaffold was produced via wet-electrospinning of cellulose acetate/gelatin solution into the gabapentin containing coagulation bath. The produced scaffold was shown to be compatible with SCs, as the major cells to support the repair and regeneration of injured peripheral nerves.

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Why is it important?

Neural repair following peripheral nerve injury is limited and often needs sophisticated surgical procedures to bridge the nerve gaps. Neural tissue engineering scaffolds in the form of neural guidance conduits (NGCs) have become suitable substitutes. In vivo study on a sciatic nerve defect model revealed that the GBP-containing scaffold significantly enhanced the regeneration of created injury compared with the GBP-free CA/Gel scaffold which demonstrates its applicability for the neural tissue engineering applications.